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Products: Primary Antibodies

Anti-Kir2.3 K+ channel Antibody (N25/35)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-069
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-069
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

Inward rectifier potassium channel 4 or Kir2.3 is encoded by the gene KCNJ4. Kir2.3 is a member of the inward rectifier potassium ion channel family and plays a role in excitability of muscle cells and neurons. Kir2.3 is an integral membrane protein that is found expressed in heart, skeletal muscle, and several different brain regions including the hippocampus. Diseases associated with KCNJ4 include Long Qt Syndrome 9 and Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance.

Immunogen:

Fusion protein amino acids 390-445 of human Kir2.3 (accession number NP_032453); Mouse: 96% identity (55/57 amino acids identical); Rat: 94% identity (54/57 amino acids identical)

Cross Reactivity:

No cross-reactivity against Kir2.1 or Kir2.2

Protein Name(s):

Kir2.3 K+ channel

Gene Name(s):

KCNJ4 IRK3

Antibody Registry ID:

Purified: AB_2130742
TC Supernatant: AB_10673968


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

45 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.