Human Mouse Rat
IHC IP WB
Inositol 1,4,5-trisphosphate receptor type 1 or IP3 receptor type 1 (IP3R1) serves as a receptor for IP3. It is expressed in many tissues in the endoplasmic reticulum to facilitate calcium release from the ER. In brain, (IP3R1) is predominantly expressed in cerebellar Purkinje neurons.. Mutations in this gene cause spinocerebellar ataxia type 15 and spinocerebellar Ataxia 29.
Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type 1 IP3R accession number P29994); Human: 100% identity (70/70 amino acids); Mouse: 100% identity (70/70 amino acids); Rat type 2 IP3R: 66% identity (46/70 amino acids); Rat type 3 IP3R: 56% identity (39/70 amino acids)
Does not recognize type 2 and type 3 IP3R’s
IP3 receptor, type 1
TC Supernatant: AB_10672249
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
300 kDa(varies due to glycosylation)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.