Our mouse IP3 receptor, type 1 monoclonal antibody from NeuroMab is produced in-house from clone L24/18. It detects canine, human, mouse, and rat IP3 receptor, type 1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.
Inositol 1,4,5-trisphosphate receptor type 1 or IP3 receptor type 1 (IP3R1) serves as a receptor for IP3. It is expressed in many tissues in the endoplasmic reticulum to facilitate calcium release from the ER. In brain, (IP3R1) is predominantly expressed in cerebellar Purkinje neurons.. Mutations in this gene cause spinocerebellar ataxia type 15 and spinocerebellar Ataxia 29.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
L24/18
IgG1
ELISA, ICC, IHC, IP, WB
Mouse
Itpr1 Insp3r
300 kDa (varies due to glycosylation)
Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type 1 IP3R (accession number P29994) produced recombinantly in E. Coli
Rat
Canine, Human, Mouse, Rat
AB_10000362
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
IHC: 1:100
ICC: 1:100
Unconjugated
Does not recognize type 2 and type 3 IP3R’s
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
![Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/files/75-035-l24-18-wb-3_120x120.png?v=1702670832)
