Human Mouse Rat
IHC IP WB
Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, accession number Q9JKB0)
Mouse: 96% identity (128/133 amino acids identical)
Human: 90% identity (121/133 amino acids identical)
<50% identity with HCN2, HCN3 and HCN4
No cross-reactivity against HCN2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
TC Supernatant: AB_10672848
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.