Anti-HCN1 Antibody FL490 Conjugate (N70/28)

Name: Anti-HCN1 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-110-FL490
Price: 531.0 USD
Availability: InStock

Our Anti-HCN1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N70/28. It is KO validated, detects human, mouse, and rat HCN1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Gerbil, Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-110-FL490

Volume: 200 µL

Variant

Price:

$531.00

Quantity:

Ships: 1-5 business days

Product Details

Target

HCN1

Target Description

HCN1 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN1 is found in the hippocampus, neocortex, and cerebellar cortex of brain. Alterations in this protein have been implicated in the disease early infantile epileptic encephalopathy.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N70/28

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Hcn1

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (accession number Q9JKB0); Mouse: 96% identity (128/133 amino acids identical) produced recombinantly in E. Coli

Species Reactivity

Gerbil, Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939412

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against HCN2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

UniProt ID

Q9JKB0

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Anti-HCN1 Antibody FL490 Conjugate (N70/28)

SKU: 75-110-FL490

Product Details

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