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Products: Primary Antibodies

Anti-GRK6A/B Antibody (N142/28)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-176
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-176
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Mouse

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

G-protein coupled receptor kinase 6 is encoded by the gene GRK6. GRK6 is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily. GRK6 phosphorylates the activated forms of G-protein coupled receptors, thus initiating their deactivation. GRK6 is expressed in the brain in striatal neurons and spleen. No disorders were found to be associated with GRK6.

Immunogen:

Fusion protein amino acids 371-576 (C-terminus) of mouse GRK6A(also known as G protein-coupled receptor kinase 6A and Gprk6A, accession number O70293); Rat: 98% identity (203/206 amino acids identical); Human: 95% identity (197/206 amino acids identical); 100% identity with GRK6B (189/189 amino acids identical, amino acids 371-559); Greater than 55% identity with GRK5 and GRK4

Cross Reactivity:

Cross-reacts with GRK6B

Protein Name(s):

GRK6A/B

Gene Name(s):

Grk6 Gprk6

Antibody Registry ID:

Purified: AB_2115469
TC Supernatant: AB_10673967


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

65 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.