Human Mouse Rat
IHC IP WB
Copper-transporting ATPase 2 or Copper-transporting ATPase Beta is encoded by the gene ATP7B and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 2 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the golgi network and is also to remove excess copper across plasma membranes out of the cell Copper-transporting ATPase 2 is expressed in liver and in lower leves in brain, heart, kidney, placenta and lung. In liver, it is involved in removing copper from hepatocytes into the bile for removal. Diseases associated with this gene include Wilson Disease and Menkes Disease.
Synthetic peptide amino acids 3-21 (cytoplasmic N- terminus) of human Copper-transporting ATPase 2 (Copper pump 2) (Wilsons disease-associated protein) (accession number P35670); Rat: 78% identity (15/19 amino acids); Mouse=84% identity (16/19 amino acids)
No cross-reactivity reported
Copper ATPase 2 (Wilson's disease protein)
ATP7B PWD WC1 WND
TC Supernatant: AB_10672737
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
160 kDa in rat brain membrane preparations
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.