Human Mouse Rat
IHC IP WB
PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.
Fusion protein amino acids 1-852 of rat Chapsyn-110 (accession number Q63622); Human: 94% identity (826/870 amino acids identical); Mouse=99% identity (846/852 amino acids identical)
No cross-reactivity against other MAGUK family members PSD-95, SAP97, SAP102 expressed in transfected cells
TC Supernatant: AB_10673100
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.