Anti-Cavbeta2 Ca2+ Channel Antibody (N8B/1)

Name: Anti-Cavbeta2 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-065
Price: 319.0 USD
Availability: InStock

7 Citations

Our Anti-Cavbeta2 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N8B/1. It detects human, mouse, and rat Cavbeta2 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in CM, IHC, ICC, IP, WB.

Adult rat pontine nucleus immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Adult rat pontine nucleus immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-065

Volume: 100 µL

Variant

Price:

$319

Quantity:

Product Details

Target

Cavbeta2 Ca2+ channel

Target Description

Voltage-dependent L-type calcium channel subunit beta-2 or Cav ß2 is encoded by the gene CACNB2. Cavß2 is a cytoplasmic subunit of L type voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß2 is expressed heart and brain, and lung. Mutations in this gene are associated with Brugada syndrome.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N8B/1

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Cacnb2 Cacnlb2

Molecular Weight

78 kDa

Antigen

Synthetic peptide amino acids 189-205 of rat Cav2 (RSPKPSANSVTSPHSKE; accession number A0A0G2JSZ0)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2069734

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Cavβ1, Cavβ3, Cavβ4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2)

UniProt Details

UniProt (Human): Q08289
UniProt (Immunogen Species): A0A0G2JSZ0

Product Specific References for Applications and Species

Immunocytochemistry: Rat
Immunohistochemistry: Human
Western Blot: Mouse | Rat

Immunocytochemistry: Rat
PMID	Dilution	Publication
20509142	5µg/ml	Ortiz-Miranda, S., et al. 2010. Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals. Journal of cellular physiology, 276-288.
19858357	1:1000	Heneghan, J., et al. 2009. The Ca2+ channel beta subunit determines whether stimulation of Gq-coupled receptors enhances or inhibits N current. The Journal of general physiology, 369-384.

Immunocytochemistry: Human
PMID	Dilution	Publication
28739256	not listed	Kazim, A., et al. 2017. Palmitoylation of Ca2+ channel subunit CaVβ2a induces pancreatic beta-cell toxicity via Ca2+ overload. Biochemical and biophysical research communications, 740-746.

Western Blot: Mouse
PMID	Dilution	Publication
32616470	1:50	Held, R., et al. 2020. Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry. Neuron, 667-683.
19840220	not listed	Abiria, S., et al. 2010. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. Journal of neurochemistry, 150-161.

Western Blot: Rat
PMID	Dilution	Publication
24681347	not listed	Liu, W., et al. 2014. KCNE2 modulates cardiac L-type Ca(2+) channel. Journal of molecular and cellular cardiology, 208-218.
19840220	not listed	Abiria, S., et al. 2010. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. Journal of neurochemistry, 150-161.

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Anti-Cavbeta2 Ca2+ Channel Antibody (N8B/1)

SKU: 75-065

Product Details

Product Specific References for Applications and Species

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