Anti-Ataxin-1, WT Antibody (N65/37)

Name: Anti-Ataxin-1, WT Antibody
Brand: NeuroMab
SKU: 75-102
Price: 337.0 USD
Availability: InStock

Our mouse Ataxin-1, WT monoclonal antibody from NeuroMab is produced in-house from clone N65/37. It detects human, mouse, and rat Ataxin-1, WT and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS-1 cells transfected with Ataxin- 1-WT, Ataxin-1-S751A or Kv2.1 plasmid and probed with N65/37 TC supe.

Adult rat cerebellum immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-102

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Ataxin-1, WT

Scientific Background

Ataxin1, also known as spinocerebellar ataxia type 1 protein homolog, is a highly conserved DNA-binding protein. Ataxin1 is expressed in brain and can be found at high levels in the cortex and the hypothalamus in neurons. It is also expressed in other tissues. Within the cell, it is highly expressed in the nucleus, and can also be found in the cytoplasm. Mutations in the ataxin-1 gene cause spinocerebellar ataxia type 1.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N65/37

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Atxn1 Sca1

Molecular Weight

85 kDa

Immunogen

Synthetic peptide amino acids 746-761 (RKRRRWSAPETRKLEK) of mouse ataxin-1 (accession number P54254)

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10675132

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.30

Conjugate

Unconjugated

Specificity

Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot (right)

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Ataxin-1 (Spinocerebellar ataxia type 1 protein homolog)

UniProt ID

P54254

Shipping

Shipped on ice packs

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Anti-Ataxin-1, WT Antibody (N65/37)

SKU: 75-102

Product Details

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