Anti-TMEM240 Recombinant Chicken Chimeric mAb (BSA and Azide free) (N498/28)

Name: Anti-TMEM240 Recombinant Chicken Chimeric mAb (BSA and Azide free)
Brand: Aves Labs
SKU: 78-533-CF
Price: 522.0 USD
Availability: InStock

Our chicken Anti-TMEM240 carrier-free recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N498/28. It detects human, mouse, and rat TMEM240 and is purified by affinity chromatography. It works in ELISA, ICC, IHC, WB.

Anti-TMEM240 Recombinant Chicken Chimeric mAb (BSA and Azide free)

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

490

550

594

650

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Data Sheet

Trial Size

SKU: 78-533-CF

Volume: 100 µL

Variant

Price:

$522.00

Quantity:

Ships: 1-2 business days

Product Details

Target

TMEM240

Scientific Background

The TMEM240 (Transmembrane Protein 240) gained significant attention in the 2010s when it was linked to the neurodegenerative disorder Spinocerebellar Ataxia Type 21 (SCA21). TMEM240 is a small transmembrane protein highly expressed in the central nervous system, particularly within the Purkinje cells of the cerebellum and the synapses of the cerebral cortex. While its precise biochemical pathway is still being studied, research suggests it plays a vital role in maintaining synaptic integrity and intracellular signaling. Mutations in the TMEM240 gene lead to the misfolding or loss of function of the protein, which triggers the progressive motor incoordination and cognitive impairment characteristic of SCA21.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N498/28

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

TMEM240

Molecular Weight

20 kDa

Excitation / Emission

Unconjugated

Immunogen

Recombinant protein comprising amino acids 26-89 (ER luminal domain) and 111-173 (cytoplasmic domain) of human TMEM240 (SCA21; C1orf70, TMEM240, accession number Q5SV17) connected by a Gly8 linker, produced recombinantly in E. Coli.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N498/28 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N498/28 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Buffer

PBS

Dilution Ranges

WB: 1:500-1:2000
WB Brain: 1:500-1:2000
IHC: 1:100-1:500
ICC: 1:100-1:500

Conjugate

Unconjugated, Carrier Free

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

TMEM240, C1orf70

UniProt ID

Q5SV17

Shipping

Shipped on ice packs

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Anti-TMEM240 Recombinant Chicken Chimeric mAb (BSA and Azide free) (N498/28)

SKU: 78-533-CF

Product Details

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