Anti-Teneurin-3 Recombinant Chicken Chimeric mAb FL650 Conjugate (N497/10)

Name: Anti-Teneurin-3 Recombinant Chicken Chimeric mAb FL650 Conjugate
Brand: Aves Labs
SKU: 78-532-FL650
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Teneurin-3 FL650 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N497/10. It detects human, mouse, and rat Teneurin-3 and is purified by affinity chromatography. Works in ICC, IHC.

Anti-Teneurin-3 Recombinant Chicken Chimeric mAb FL650 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 78-532-FL650

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Teneurin-3

Scientific Background

Teneurin-3 is a large type II transmembrane protein belonging to the teneurin family, which plays essential roles in neuronal connectivity, cell adhesion, and developmental patterning. Structurally, Teneurin-3 contains a large extracellular domain with EGF-like repeats, NHL and YD-repeat motifs, and a unique C-terminal peptide sequence implicated in intercellular signaling. It mediates homophilic and heterophilic interactions that guide axon targeting and synapse specificity, particularly in the visual and hippocampal systems. Teneurin-3 interacts with latrophilins and other synaptic adhesion molecules to regulate synaptogenesis and neuronal circuit formation. Genetic disruption or altered expression of TENM3 has been linked to neurodevelopmental disorders, visual pathway defects, and certain cancers, highlighting its significance in neural development and disease.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

N497/10

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

Tenm3

Molecular Weight

303 kDa

Excitation / Emission

FL650 Ex: 655 nm, Em: 676 nm

Immunogen

Recombinant protein comprising amino acids aa 161-201 and 343-396 (extracellular and cytoplasmic domains) of mouse Teneurin-3 (Tenm3, accession number Q9WTS6) connected by a Gly8 linker, produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N497/10 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N497/10 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

650

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

MCOPCB9; Tenm3; TNM3; Ten-m3; ten-3; teneurin-3; ODZ3-like protein; odz; odd Oz/ten-m homolog 3; protein Odd Oz/ten-m homolog 3; tenascin-M3; testicular tissue protein Li 195

UniProt ID

Q9WTS6
UniProt Summary: Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes.

NCBI Gene ID

55714

Shipping

Shipped on ice packs

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Anti-Teneurin-3 Recombinant Chicken Chimeric mAb FL650 Conjugate (N497/10)

SKU: 78-532-FL650

Product Details

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