Anti-Teneurin-3 Recombinant Chicken Chimeric mAb (N497/10)

Name: Anti-Teneurin-3 Recombinant Chicken Chimeric mAb
Brand: Aves Labs
SKU: 78-532
Price: 470.0 USD
Availability: InStock

Our chicken Anti-Teneurin-3 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N497/10. It detects human, mouse, and rat Teneurin-3, and is purified by affinity chromatography. It is great for use in ELISA, ICC, IHC, WB.

Representative image of formalin fixed paraffin embedded section of rat cerebellum section stained with anti-Teneurin-3 recombinant chicken monoclonal antibody (brown, Cat No. 78-532) and counterstained with hematoxylin (blue). Magnification: 200X

Western blotting of rat brain membrane with NeuroMab anti-Teneurin-3 mouse mAb TC supe (Clone N497/10) and with Aves Labs anti-Teneurin-3 recombinant chicken mAb antibody (Cat No. 78-532) recognizing endogenous Teneurin-3 at ~300 kDa with similar sensitivity. The mouse mAb and chicken mAb were detected with anti-mouse-HRP and anti-chicken-HRP (Cat No. 80-1000-HRP), respectively.

Immunohistochemistry staining of cerebellum region from adult rats using anti-Teneurin-3 NeuroMab mouse monoclonal antibody (Clone N497/10). The variable region of this antibody was used to generate recombinant chicken chimeric anti-Teneurin-3 antibody (Cat No. 78-532).

Representative image of formalin fixed paraffin embedded section of rat cerebellum section stained with anti-Teneurin-3 recombinant chicken monoclonal antibody (brown, Cat No. 78-532) and counterstained with hematoxylin (blue). Magnification: 200X

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

Trial Size

SKU: 78-532

Volume: 100 µL

Variant

Price:

$470.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Teneurin-3

Scientific Background

Teneurin-3 is a large type II transmembrane protein belonging to the teneurin family, which plays essential roles in neuronal connectivity, cell adhesion, and developmental patterning. Structurally, Teneurin-3 contains a large extracellular domain with EGF-like repeats, NHL and YD-repeat motifs, and a unique C-terminal peptide sequence implicated in intercellular signaling. It mediates homophilic and heterophilic interactions that guide axon targeting and synapse specificity, particularly in the visual and hippocampal systems. Teneurin-3 interacts with latrophilins and other synaptic adhesion molecules to regulate synaptogenesis and neuronal circuit formation. Genetic disruption or altered expression of TENM3 has been linked to neurodevelopmental disorders, visual pathway defects, and certain cancers, highlighting its significance in neural development and disease.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N497/10

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

Tenm3

Molecular Weight

303 kDa

Excitation / Emission

Unconjugated

Immunogen

Recombinant protein comprising amino acids aa 161-201 and 343-396 (extracellular and cytoplasmic domains) of mouse Teneurin-3 (Tenm3, accession number Q9WTS6) connected by a Gly8 linker, produced recombinantly in E.Coli.

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions clone N497/10 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N497/10 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
IHC: 1:100

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Tenm3

Shipping

Shipped on ice packs

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Anti-Teneurin-3 Recombinant Chicken Chimeric mAb (N497/10)

SKU: 78-532

Product Details

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