Bulk Order Anti-Synaptotagmin-3 Antibody FL550 Conjugate
Synaptotagmins are a family of calcium sensing, membrane trafficking proteins. 17 different synaptotagmins have been identified in mammals. Synaptotagmin 3 is predominantly expressed in postsynaptic endocytic zones of neurons and has recently been shown to internalize AMPA receptors to depress synaptic strength and promote forgetting (Awasthi A. et al., 2019).
Purified by Protein A chromatography
Fusion protein amino acids 442-533 (cytoplasmic C2B domain) of mouse Synaptotagmin-3 (accession number O35681) produced recombinantly in E. Coli
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
Does not cross-react with other Synaptotagmins
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.