Anti-Synaptotagmin-10 Antibody (BSA and Azide free) (N269/73)

Name: Anti-Synaptotagmin-10 Antibody (BSA and Azide free)
Brand: NeuroMab
SKU: 75-262-CF
Price: 486.0 USD
Availability: InStock

Our mouse Synaptotagmin-10 carrier-free monoclonal antibody from NeuroMab is produced in-house from clone N269/73. It detects mouse and rat Synaptotagmin-10 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Anti-Synaptotagmin-10 Antibody (BSA and Azide free)

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

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Data Sheet

SKU: 75-262-CF

Volume: 100 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Synaptotagmin-10

Scientific Background

Synaptotagmins are a family of calcium sensing, membrane trafficking proteins. 17 different synaptotagmins have been identified in mammals. Synaptotagmin 10 has been shown to function as the Ca2+-sensor that triggers IGF-1 exocytosis in olfactory bulb neurons (Cao P. et al., 2011).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.6-1.0 mg/mL

Clonality

Monoclonal

Clone

N269/73

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Syt10

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 248-335 (cytoplasmic C2A domain) of mouse Synaptotagmin-10 (accession number Q9R0N4) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and buffer exchanged into 1X PBS. Purified mAbs are >90% specific antibody.

Buffer

PBS

Conjugate

Unconjugated

Specificity

Does not cross-react with Synaptotagmin-6 or Synaptotagmin-3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

synaptotagmin-10; Synaptotagmin X; SytX

UniProt ID

Q9R0N4
UniProt Summary: Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis.

NCBI Gene ID

54526

Shipping

Shipped on ice packs

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Anti-Synaptotagmin-10 Antibody (BSA and Azide free) (N269/73)

SKU: 75-262-CF

Product Details

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