Anti-Shank3 Antibody FL550 Conjugate (N69/46)

Name: Anti-Shank3 Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-109-FL550
Price: 445.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

Unconjugated

490

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N69/46

Applications

ICC, IHC

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

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Volume: 200 µL

Variant

Price:

$445

Quantity:

Bulk Order Anti-Shank3 Antibody FL550 Conjugate

Product Details

Target

Shank3

Target Description

SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N69/46

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

Antigen

Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (accession number Q9JLU4)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939409

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity against Shank1 or Shank2

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

UniProt Details

UniProt (Human): Q9BYB0
UniProt (Immunogen Species): Q9JLU4

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Anti-Shank3 Antibody FL550 Conjugate (N69/46)

Available Conjugates

Anti-Shank3 Antibody FL550 Conjugate
SKU: 75-109-FL550

Bulk Order Anti-Shank3 Antibody FL550 Conjugate

Product Details

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Anti-Shank3 Antibody FL550 Conjugate (N69/46)

Available Conjugates

Anti-Shank3 Antibody FL550 Conjugate SKU: 75-109-FL550

Bulk Order Anti-Shank3 Antibody FL550 Conjugate

Product Details

Anti-Shank3 Antibody FL550 Conjugate
SKU: 75-109-FL550