Anti-Shank3 Antibody (N69/46)

Name: Anti-Shank3 Antibody
Brand: NeuroMab
SKU: 75-109
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N69/46

Applications

IHC, IP, WB

Host Species

Mouse

Format

Purified

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

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Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2, Shank3 or Kv2.1 plasmids and probed with N69/46 TC supe (left panel) or a monoclonal lane loading control (right panel).

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

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$295

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Product Details

Target

Shank3

Target Description

SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N69/46

Isotype

IgG2b

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Shank3 Prosap2

Molecular Weight

190 kDa

Antigen

Synthetic peptide amino acids 840-857 (PEKLPGSLRKGIPRTKSV) of rat Shank3 (also known as SH3 and multiple ankyrin repeat domains protein 3, prolinerich synapse-associated protein 2, ProSAP2 and SPANK-2, accession number Q9JLU4); Human: 100% identity (18/18 amino acids identical); Mouse: 100% identity (18/18 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2187730

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against Shank1 or Shank2

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

UniProt Details

UniProt (Immunogen Species): Q9JLU4

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Anti-Shank3 Antibody (N69/46)

Anti-Shank3 Antibody
SKU: 75-109

Bulk Order Anti-Shank3 Antibody

Product Details

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Anti-Shank3 Antibody (N69/46)

Anti-Shank3 Antibody SKU: 75-109

Bulk Order Anti-Shank3 Antibody

Product Details

Anti-Shank3 Antibody
SKU: 75-109