Anti-Shank1 Antibody FL490 Conjugate (N22/21)

Name: Anti-Shank1 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-064-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-Shank1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N22/21. It detects human, mouse, and rat Shank1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: 75-064-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Shank1

Target Description

SH3 and multiple ankyrin repeat domains protein 1, or shank 1 is a member of the shank family. Shank 1 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Unlike other shank family proteins, shank 1 is found in only in brain in the neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum, amygdala, substantia nigra and thalamus. Cellularly, shank 1 can be found in cytoplasm, cell junctions, postsynaptic cell membrane and postsynaptic density. Many isoforms of shank 1 exist, and some are expressed during development, while others are expressed in mature tissue. Shank 1 acts as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 1 may play a role in synapse formation and dendritic spine maturation. Mutations in this gene have been associated with autism spectrm disorder and diabetic encephalopathy.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N22/21

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Shank1

Molecular Weight

190-220 kDa (alternative splice variants)

Antigen

Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939268

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against Shank2 or Shank3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)

UniProt Details

UniProt (Human): Q9Y566
UniProt (Immunogen Species): Q9WV48

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Anti-Shank1 Antibody FL490 Conjugate (N22/21)

SKU: 75-064-FL490

Product Details

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