Anti-Shank1 Antibody (N22/21)

Name: Anti-Shank1 Antibody
Brand: NeuroMab
SKU: 75-064
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, WB

Host Species

Mouse

Gene Name

Shank1

Molecular Weight

190-220 kDa (alternative splice variants)

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Transfected cell immunofluorescence staining N22/21=green, rabbit anti-Shank1=red, DAPI=blue.

Adult rat brain membrane immunoblot.

Product Details

Target

Shank1

Target Description

SH3 and multiple ankyrin repeat domains protein 1, or shank 1 is a member of the shank family. Shank 1 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Unlike other shank family proteins, shank 1 is found in only in brain in the neuropil of cortex, CA1 region hippocampus and molecular layer of cerebellum, amygdala, substantia nigra and thalamus. Cellularly, shank 1 can be found in cytoplasm, cell junctions, postsynaptic cell membrane and postsynaptic density. Many isoforms of shank 1 exist, and some are expressed during development, while others are expressed in mature tissue. Shank 1 acts as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 1 may play a role in synapse formation and dendritic spine maturation. Mutations in this gene have been associated with autism spectrm disorder and diabetic encephalopathy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N22/21

Isotype

IgG1

Applications

IHC, WB

Host Species

Mouse

Gene Name

Shank1

Molecular Weight

190-220 kDa (alternative splice variants)

Antigen

Fusion protein amino acids 469-691 (SH3/PDZ domains) of rat Shank1 (accession number Q9WV48); Human: 96% identity (215/223 amino acids identical); Mouse: 100% identity (223/223 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2270283

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against Shank2 or Shank3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon)

UniProt Details

UniProt (Human): Q9Y566
UniProt (Immunogen Species): Q9WV48

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Anti-Shank1 Antibody (N22/21)

Anti-Shank1 Antibody
SKU: 75-064

Product Details

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Anti-Shank1 Antibody (N22/21)

Anti-Shank1 Antibody SKU: 75-064

Product Details

Anti-Shank1 Antibody
SKU: 75-064