Tissue and transfected cell immunoblot: low speed pellet samples from adult rat brain (RBLSP) and extracts of COS cells transiently transfected with Myc-tagged PEX6 or untagged Kv2.1 plasmids and probed with N233/8 (left) and K89/34 (right).
Peroxisomal Biogenesis Factor 6 is encoded by the gene PEX6. PEX6 is a member of the AAA ATPase family. PEX6 is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 receptor activity. PEX6 is expressed in the retina. Diseases associated with PEX6 include Peroxisome Biogenesis Disorder 4A and Heimler Syndrome 2.
Fusion protein amino acids 2-294 (N-terminus) of human PEX6 (also known as Peroxisome assembly factor 2, Peroxisomal biogenesis factor 6, Peroxisomal-type ATPase 1, Peroxin-6, PAF-2, PXAAA1, accession number Q8BR86-3); Rat: 82% identity (243/293 amino acids identical); Mouse: 82% identity (244/294 amino acids identical)
Less than 50% identity with other PEX proteins
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