Anti-NR2A Glutamate Receptor Antibody (N327A/38)

Name: Anti-NR2A Glutamate Receptor Antibody
Brand: NeuroMab
SKU: 73-303
Price: 337.0 USD
Availability: InStock

Our mouse NR2A glutamate receptor monoclonal antibody from NeuroMab is produced in-house from clone N327A/38. It detects human, mouse, and rat NR2A glutamate receptor and is TC supernatant. Works in WB, IHC, ELISA.

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged NR2A, NR2B or untagged Kv2.1 plasmid and probed with N327A/38 (left) and N86/38 (right) TC supe.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 73-303

Volume: 5 mL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

NR2A glutamate receptor

Scientific Background

Glutamate receptor NMDA2A or GluN2A/NR2A glutamate receptor is a member of the glutamate-gated ion channel family. NR2A is a subunit of the ligand-gated ion channel with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2A is expressed throughout the brain, including striatum, forbrain, cerebellum (at protein level) brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. It is found at the postsynaptic cell membrane, dendritic spine, synapse, and cytoplasmic vesicle membrane. A variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia are associated with mutations in the NR2A gene.

Format

TC Supernatant

Concentration

Lot dependent

Clonality

Monoclonal

Clone

N327A/38

Isotype

IgG2b

Applications

ELISA, IHC, WB

Host Species

Mouse

Gene Name

Grin2a

Molecular Weight

170 kDa

Immunogen

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (accession number Q00959) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315843

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Supernatant is harvested from hybridoma cells grown under standard cell culture conditions

Buffer

Supernatant is provided in cell culture medium with 0.1% sodium azide as anti-microbial

Conjugate

Unconjugated

Specificity

Does not cross-react with NR2B

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

EPND; Glutamate receptor ionotropic; FESD; GluN2A; GluN2A; Glutamate [NMDA receptor subunit epsilon-1; Glutamate [NMDA receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; Glutamate receptor; NMDAR2A; Glutamate receptor ionotropic N methyl D aspartate 2A; NR2A; GRIN 2A; GRIN2A; hNR2A; LKS; N methyl D aspartate receptor channel subunit epsilon 1; N Methyl D Aspartate Receptor Subtype 2A; N methyl D aspartate receptor subunit 2A; N-methyl D-aspartate receptor subtype 2A; NMDA receptor subtype 2A; NMDAR 2A; NMDAR2A; NMDE1_HUMAN; NR2A; OTTHUMP00000160135; OTTHUMP00000174531; NMDA 2A

UniProt ID

Q00959
UniProt Summary: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (Probable). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte.

NCBI Gene ID

24409

Shipping

Shipped on ice packs

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Anti-NR2A Glutamate Receptor Antibody (N327A/38)

SKU: 73-303

Product Details

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