Sodium Leak Channel, Non-Selective is encoded by the gene NALCN. NALCN is a member of the cation-nonselective channel family. NALCN is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium, and calcium ions. NALCN regulates the resting membrane potential and controls neuronal excitability. NALCN is expressed in the brain, heart, and pancreas. Diseases associated with NALCN include Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay and Hypotonia, Infantile, with Psychomotor Retardation and Characteristic Facies 1.
Purified
1 mg/mL
Monoclonal
N185/7
IgG1
ICC, WB
Mouse
Nalcn Nca Rb21 Vgcnl1
200 kDa
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN (also known as Sodium leak channel non-selective protein, Four domain-type voltage-gated ion channel alpha-1 subunit, Voltage-gated channel-like protein 1, Vgcnl1, Nca and Cankon, accession number Q6Q760); Mouse: 98% identity (79/80 amino acids identical); Human: 95% identity (76/80 amino acids identical)
Mouse, Rat
AB_2149984
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from opening
Sodium leak channel non-selective protein (Four domain-type voltage-gated ion channel alpha-1 subunit) (Rb21-channel) (Voltage gated channel-like protein 1)
