Sodium Leak Channel, Non-Selective is encoded by the gene NALCN. NALCN is a member of the cation-nonselective channel family. NALCN is a voltage-independent, cation-nonselective channel which is permeable to sodium, potassium, and calcium ions. NALCN regulates the resting membrane potential and controls neuronal excitability. NALCN is expressed in the brain, heart, and pancreas. Diseases associated with NALCN include Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay and Hypotonia, Infantile, with Psychomotor Retardation and Characteristic Facies 1.
Nalcn Nca Rb21 Vgcnl1
Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN (also known as Sodium leak channel non-selective protein, Four domain-type voltage-gated ion channel alpha-1 subunit, Voltage-gated channel-like protein 1, Vgcnl1, Nca and Cankon, accession number Q6Q760); Mouse: 98% identity (79/80 amino acids identical); Human: 95% identity (76/80 amino acids identical)
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