Anti-Mortalin/GRP75 Antibody (N52A/42)

Name: Anti-Mortalin/GRP75 Antibody
Brand: NeuroMab
SKU: 75-127
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N52A/42

Applications

IHC, IP, WB

Host Species

Mouse

Format

Purified

Gene Name

Hspa9 Grp75 Hsp74 Hspa9a

Molecular Weight

75 kDa

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Immunoblot against crude membranes prepared from whole rat (RBM) and mouse (MBM) brain and human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)] probed with N52A/42 TC supe.

Adult rat hippocampus immunohistochemistry.

Immunoblot against crude C. elegans worm extracts and RBM probed with N52A/42 TC supe.

Immunoblot against HEK293 cells transfected as shown. Note that GRP75 is endogenously expressed in HEK (and COS) cells and the relatively weak RBM staining is due to short film exposure time. Cell samples courtesy of Gino Cortopassi (UC Davis).

Immunoblot against crude membranes prepared from whole rat (RBM) and mouse (MBM) brain and human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)] probed with N52A/42 TC supe.

Volume: 100 µL

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Product Details

Target

Mortalin/GRP75

Target Description

Mitochondrial stress-70 protein or Mortalin/GRP75 is encoded by the gene HSPA9. Mortalin is a chaperone protein and plays a role in cell proliferation, stress response and mitochondria maintenance. It is widely expressed in tissues in mitochondria, endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. Diseases associated with this gene include Even-Plus Syndrome and Sideroblastic Anemia 4.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N52A/42

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Hspa9 Grp75 Hsp74 Hspa9a

Molecular Weight

75 kDa

Antigen

Identified as off-target mAb in screen for anti-Salm2 NeuroMabs (immunogen was fusion protein amino acids 551-766 of mouse SALM2; see N52B/27 data sheet). Target identified as Mortalin/Grp75 by LC-MS/MS analysis of protein immunopurified from rat brain using N52A/42.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2120479

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Stress-70 protein, mitochondrial (75 kDa glucose-regulated protein) (GRP-75) (Heat shock 70 kDa protein 9) (Mortalin) (Peptide-binding protein 74) (PBP74) (p66 MOT)

UniProt Details

UniProt (Human): P38646
UniProt (Immunogen Species): P38647

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Anti-Mortalin/GRP75 Antibody (N52A/42)

Anti-Mortalin/GRP75 Antibody
SKU: 75-127

Bulk Order Anti-Mortalin/GRP75 Antibody

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Anti-Mortalin/GRP75 Antibody (N52A/42)

Anti-Mortalin/GRP75 Antibody SKU: 75-127

Bulk Order Anti-Mortalin/GRP75 Antibody

Product Details

Anti-Mortalin/GRP75 Antibody
SKU: 75-127