Leucine Rich Repeat Transmembrane Neuronal 2 is encoded by the gene LRRTM2. LRRTM2 is a member of the LRRTM family. LRRTM2 is involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. LRRTM2 regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. LRRTM2 is expressed in neuronal tissues. Diseases associated with LRRTM2 include Histrionic Personality Disorder.
Purified by Protein A chromatography
LRRTM2 KIAA0416 LRRN2
80 kDa (and larger due to glycosylation)
Synthetic peptide amino acids 475-489 (MSNMSDQGPYNEYEP, cytoplasmic C-terminus) of human LRRTM2 (accession number O43300)
Human, Mouse, Rat
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL650 Ex: 655 nm, Em: 676 nm
Does not cross-react with LRRTM1
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.