Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2)
Potassium voltage-gated channel subfamily D member 2 or Kv4.2 potassium channel subunit is encoded by the gene KCND2. Kv4.2 is an alpha subunit of the voltage-gated potassium channel (Shal) family and mediates transmembrane potassium transport in excitable membranes. Kv4.2 is an integral membrane protein that combines to form tetramers. Kv4.2 is detected in the heart and brain. In brain it is found at the cell junction, synapse, postsynaptic cell membrane. Diseases associated with this gene include Cycloplegia and early myoclonic encephalopathy.
Purified
1 mg/mL
Monoclonal
L28/4
IgG1
ICC, IHC, WB
Mouse
Kcnd2
70 kDa
Fusion protein amino acids 471-630 (cytoplasmic C-terminus) of rat Kv4.2 (Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2, Kcnd2, Kiaa1044, MNCb-7013, RK5 and Shal1, accession number Q63881); Mouse: 99% identity (159/160 amino acids identical); Human: 98% identity (157/160 amino acids identical); Less than 50% identity with Kv4.3
Human, Mouse, Rat
AB_2315874
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Unconjugated
Does not cross-react with Kv4.3 (based on KO validation results)
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from opening
Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2)
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebellum [HBM(Cb)] or cerebral cortex [HBM(Cx)] and probed with L28/4 (left) or N52A/42 (right) TC supe.](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-361-l28-4-wb2_{width}x.jpg?v=1626903294)
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebellum [HBM(Cb)] or cerebral cortex [HBM(Cx)] and probed with L28/4 (left) or N52A/42 (right) TC supe.](http://cdn.shopify.com/s/files/1/0014/8806/0475/products/validation-image-73-361-l28-4-wb2_1024x.jpg?v=1626903294)