Anti-Kv4.2 Potassium Channel Antibody (L28/4)

Name: Anti-Kv4.2 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-361
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L28/4

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Kcnd2

Molecular Weight

70 kDa

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Adult rat hippocampus immunohistochemistry.

Immunoblot against crude brain membranes from adult rat (RBM) and wild-type (WT) and Kv4.2 knockout (KO) mice probed with L28/4 (left) or N52A/42 (right) TC supe.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebellum [HBM(Cb)] or cerebral cortex [HBM(Cx)] and probed with L28/4 (left) or N52A/42 (right) TC supe.$

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

Price:

$295

Quantity:

Bulk Order Anti-Kv4.2 Potassium Channel Antibody

Product Details

Target

Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2)

Target Description

Potassium voltage-gated channel subfamily D member 2 or Kv4.2 potassium channel subunit is encoded by the gene KCND2. Kv4.2 is an alpha subunit of the voltage-gated potassium channel (Shal) family and mediates transmembrane potassium transport in excitable membranes. Kv4.2 is an integral membrane protein that combines to form tetramers. Kv4.2 is detected in the heart and brain. In brain it is found at the cell junction, synapse, postsynaptic cell membrane. Diseases associated with this gene include Cycloplegia and early myoclonic encephalopathy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L28/4

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnd2

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 471-630 (cytoplasmic C-terminus) of rat Kv4.2 (Potassium voltage-gated channel subfamily D member 2, Voltage-gated potassium channel subunit Kv4.2, Kcnd2, Kiaa1044, MNCb-7013, RK5 and Shal1, accession number Q63881); Mouse: 99% identity (159/160 amino acids identical); Human: 98% identity (157/160 amino acids identical); Less than 50% identity with Kv4.3

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315874

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Kv4.3 (based on KO validation results)

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily D member 2 (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2)

UniProt Details

UniProt (Human): Q9NZV8
UniProt (Immunogen Species): Q63881

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Anti-Kv4.2 Potassium Channel Antibody (L28/4)

Anti-Kv4.2 Potassium Channel Antibody
SKU: 75-361

Bulk Order Anti-Kv4.2 Potassium Channel Antibody

Product Details

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Anti-Kv4.2 Potassium Channel Antibody (L28/4)

Anti-Kv4.2 Potassium Channel Antibody SKU: 75-361

Bulk Order Anti-Kv4.2 Potassium Channel Antibody

Product Details

Anti-Kv4.2 Potassium Channel Antibody
SKU: 75-361