Anti-Kv1.3 K+ Channel Antibody FL490 Conjugate (L23/27)

Name: Anti-Kv1.3 K+ Channel Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-009-FL490
Price: 515.0 USD
Availability: InStock

Our Anti-Kv1.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L23/27. It is KO validated, detects human, mouse, and rat Kv1.3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

KO Validated

SKU: 75-009-FL490

Volume: 200 µL

Variant

Price:

$515.00

Quantity:

Product Details

Target

Kv1.3 K+ channel

Target Description

Kv1.3 K+ channel (also known KCNA3) is a member of the potassium channel, voltage-gated, shaker-related subfamily. This protein, encoded by the KCNA3 gene in human, is an efficient channel blocker. Kv1.3 K+ channel includes a shaker-type repeat in the fourth segment of a six membrane-spanning domains. Kv1.3 K+ channel plays a role in the repolarization of nerve cells after an action potential. It is also widely expressed on T and B lymphocytes'membranes (including inner mitochondrial membrane) and has an important function in T-cell activation, especially in the regulation of chronically activated effector memory T-cell immune responses (Chiang et al., 2017). It has been demonstrated that effector memory T-cells highly expressing Kv1.3 K+ channel are predominantely present in patient with Musltiple Sclerosis lesion and children with type-1 diabetes mellitus (Beeton et al., 2006).

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

L23/27

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Kcna3

Molecular Weight

70 kDa

Antigen

Synthetic peptide amino acids 485-506 (GGMNHSAFPQTPFKTGNSTATC, cytoplasmic C-terminus) of rat Kv1.3 (accession number P15384)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939096

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3)

UniProt Details

UniProt (Human): P22001
UniProt (Immunogen Species): P15384

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Anti-Kv1.3 K+ Channel Antibody FL490 Conjugate (L23/27)

SKU: 75-009-FL490

Product Details

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