Anti-Kv1.3 K+ Channel Antibody (L23/27)

Name: Anti-Kv1.3 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-009
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcna3

Molecular Weight

70 kDa

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Adult rat dentate gyrus immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Adult rat dentate gyrus immunohistochemistry.

Product Details

Target

Kv1.3 K+ channel

Target Description

Kv1.3 K+ channel (also known KCNA3) is a member of the potassium channel, voltage-gated, shaker-related subfamily. This protein, encoded by the KCNA3 gene in human, is an efficient channel blocker. Kv1.3 K+ channel includes a shaker-type repeat in the fourth segment of a six membrane-spanning domains. Kv1.3 K+ channel plays a role in the repolarization of nerve cells after an action potential. It is also widely expressed on T and B lymphocytes'membranes (including inner mitochondrial membrane) and has an important function in T-cell activation, especially in the regulation of chronically activated effector memory T-cell immune responses (Chiang et al., 2017). It has been demonstrated that effector memory T-cells highly expressing Kv1.3 K+ channel are predominantely present in patient with Musltiple Sclerosis lesion and children with type-1 diabetes mellitus (Beeton et al., 2006).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L23/27

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcna3

Molecular Weight

70 kDa

Antigen

Synthetic peptide amino acids 485-506 (GGMNHSAFPQTPFKTGNSTATC, cytoplasmic C-terminus) of rat Kv1.3 (also known as Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3, Kv3, KIII, GK5, K3 and Kcna3, accession number P15384) Human: 100% identity (22/22 amino acids identical) Mouse: 100% identity (22/22 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2133637

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily A member 3 (RCK3) (RGK5) (Voltage-gated potassium channel subunit Kv1.3) (Voltage-gated potassium channel subunit Kv3)

UniProt Details

UniProt (Human): P22001
UniProt (Immunogen Species): P15384

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Anti-Kv1.3 K+ Channel Antibody (L23/27)

Anti-Kv1.3 K+ Channel Antibody
SKU: 75-009

Product Details

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Anti-Kv1.3 K+ Channel Antibody (L23/27)

Anti-Kv1.3 K+ Channel Antibody SKU: 75-009

Product Details

Anti-Kv1.3 K+ Channel Antibody
SKU: 75-009