Kv1.3 K+ channel (also known KCNA3) is a member of the potassium channel, voltage-gated, shaker-related subfamily. This protein, encoded by the KCNA3 gene in human, is an efficient channel blocker. Kv1.3 K+ channel includes a shaker-type repeat in the fourth segment of a six membrane-spanning domains. Kv1.3 K+ channel plays a role in the repolarization of nerve cells after an action potential. It is also widely expressed on T and B lymphocytes'membranes (including inner mitochondrial membrane) and has an important function in T-cell activation, especially in the regulation of chronically activated effector memory T-cell immune responses (Chiang et al., 2017). It has been demonstrated that effector memory T-cells highly expressing Kv1.3 K+ channel are predominantely present in patient with Musltiple Sclerosis lesion and children with type-1 diabetes mellitus (Beeton et al., 2006).
IHC, IP, WB
Synthetic peptide amino acids 485-506 (GGMNHSAFPQTPFKTGNSTATC, cytoplasmic C-terminus) of rat Kv1.3 (also known as Potassium voltage-gated channel subfamily A member 3, Voltage-gated potassium channel subunit Kv1.3, Kv3, KIII, GK5, K3 and Kcna3, accession number P15384)
Human: 100% identity (22/22 amino acids identical)
Mouse: 100% identity (22/22 amino acids identical)
Human, Mouse, Rat
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