Serial dilutions of BSA-conjugated modified and unmodified peptides dotted onto membrane and probed with N299/39 TC supe (left) and a mouse loading control (right).
Anti-Histone H2A.Z Acetyl-Lys4/7/11 Antibody
Histone H2A.Z (H2A/z)
H2A.Z Variant Histone 1 is encoded by the gene H2AZ1. H2AZ1 is a member of the histone H2A family. H2AZ1 is a variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic fatality. H2AZ1 is expressed in 239 organs with the highest levels in the myometrium. Diseases associated with H2AZ1 include testicular spermatocytic seminoma.
Synthetic peptide amino acids 2-15 (AGG[acetyl-K]AG[acetyl-K]DSG[acetyl-K]AKT) of human Histone H2A.Z (also known as Histone H2A/Z, accession number P0C0S5); Mouse: 100% identity (14/14 amino acids identical); Human: 100% identity (14/14 amino acids identical); 93% identity with Histone H2A.V
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with unacetylated Histone H2A.Z
Does not cross-react with Histones H2A acetyl-Lys4/8 or H4 acetyl-Lys4/7/11/15
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.