Anti-HCN2 Antibody (N71/37)

Name: Anti-HCN2 Antibody
Brand: NeuroMab
SKU: 75-111
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Hcn2

Molecular Weight

95 kDa

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and of COS-1 cells transfected with GFP- HCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N71/37 (left), K89/34 (middle) or a control (right) TC supe.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Adult rat hippocampus immunohistochemistry.

Adult rat cerebellum immunohistochemistry.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and of COS-1 cells transfected with GFP- HCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N71/37 (left), K89/34 (middle) or a control (right) TC supe.

Product Details

Target

HCN2

Target Description

HCN2 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN2 is expressed throughout the brain and in high levels in thalamic and brainstem nuclei.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N71/37

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Hcn2

Molecular Weight

95 kDa

Antigen

Fusion protein amino acids 761-863 (cytoplasmic C-terminus) of rat HCN2 (also known as potassium /sodium hyperpolarization-activated cyclic nucleotide gated channel 2, accession number Q9JKA9); Mouse: 98% identity (101/103 amino acids identical); Human: 82% identity (86/104 amino acids identical); Less than 50% identity with HCN1, HCN3 and HCN4

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2279449

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against HCN1

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

UniProt Details

UniProt (Human): Q9UL51
UniProt (Immunogen Species): Q9JKA9

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Anti-HCN2 Antibody (N71/37)

Anti-HCN2 Antibody
SKU: 75-111

Product Details

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Anti-HCN2 Antibody (N71/37)

Anti-HCN2 Antibody SKU: 75-111

Product Details

Anti-HCN2 Antibody
SKU: 75-111