Anti-HCN1 Antibody (N70/28)

Name: Anti-HCN1 Antibody
Brand: NeuroMab
SKU: 75-110
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

filler

Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Hcn1

Molecular Weight

100 kDa

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Adult rat and mouse brain membrane (RBM and MBM, respectively) and transfected cell immunoblot: extracts of RBM, HCN1-KO and -WT MBM and COS-1 cells transfected with GFP-HCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N70/28 (left panel) or K89/34 TC supe (right panel).

Adult rat cerebellum immunohistochemistry.

Adult rat hippocampus immunohistochemistry.

Adult rat and mouse brain membrane (RBM and MBM, respectively) and transfected cell immunoblot: extracts of RBM, HCN1-KO and -WT MBM and COS-1 cells transfected with GFP-HCN1, GFP-HCN2 or Kv2.1 plasmids and probed with N70/28 (left panel) or K89/34 TC supe (right panel).

Product Details

Target

HCN1

Target Description

HCN1 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN1 is found in the hippocampus, neocortex, and cerebellar cortex of brain. Alterations in this protein have been implicated in the disease early infantile epileptic encephalopathy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N70/28

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Hcn1

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 778-910 (cytoplasmic C-terminus) of rat HCN1 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, accession number Q9JKB0); Mouse: 96% identity (128/133 amino acids identical); Human: 90% identity (121/133 amino acids identical); Less than 50% identity with HCN2, HCN3 and HCN4

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2115181

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against HCN2

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

UniProt Details

UniProt (Human): O60741
UniProt (Immunogen Species): Q9JKB0

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Anti-HCN1 Antibody (N70/28)

Anti-HCN1 Antibody
SKU: 75-110

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Anti-HCN1 Antibody (N70/28)

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Anti-HCN1 Antibody
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