Anti-GRK6A/B Antibody (N142/28)

Name: Anti-GRK6A/B Antibody
Brand: NeuroMab
SKU: 75-176
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

Grk6 Gprk6

Molecular Weight

65 kDa

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with untagged GRK5, GRK6 and Kv2.1 plasmids and probed with N142/28 TC supe.

Product Details

Target

GRK6A/B

Target Description

G-protein coupled receptor kinase 6 is encoded by the gene GRK6. GRK6 is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily. GRK6 phosphorylates the activated forms of G-protein coupled receptors, thus initiating their deactivation. GRK6 is expressed in the brain in striatal neurons and spleen. No disorders were found to be associated with GRK6.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N142/28

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Grk6 Gprk6

Molecular Weight

65 kDa

Antigen

Fusion protein amino acids 371-576 (C-terminus) of mouse GRK6A(also known as G protein-coupled receptor kinase 6A and Gprk6A, accession number O70293); Rat: 98% identity (203/206 amino acids identical); Human: 95% identity (197/206 amino acids identical); 100% identity with GRK6B (189/189 amino acids identical, amino acids 371-559); Greater than 55% identity with GRK5 and GRK4

Species Reactivity

Mouse

Antibody Registry ID

AB_2115469

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Cross-reacts with GRK6B

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)

UniProt Details

UniProt (Human): P43250
UniProt (Immunogen Species): O70293

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Anti-GRK6A/B Antibody (N142/28)

Anti-GRK6A/B Antibody
SKU: 75-176

Product Details

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Anti-GRK6A/B Antibody (N142/28)

Anti-GRK6A/B Antibody SKU: 75-176

Product Details

Anti-GRK6A/B Antibody
SKU: 75-176