Anti-GABA-B-R2 Antibody FL650 Conjugate (N81/2)

Name: Anti-GABA-B-R2 Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-124-FL650
Price: 460.0 USD
Availability: InStock

Our Anti-GABA(B)R2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N81/2. It is KO validated, detects human and mouse GABA(B)R2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

594

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Data Sheet

KO Validated

SKU: 75-124-FL650

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

GABA(B)R2

Target Description

Gamma-aminobutyric acid type B receptor subunit 2 or GABA BR2 is encoded by the gene GABBR2. GABA BR2 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR2 is highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. It is weakly expressed in heart, testis and skeletal muscle. Diseases associated with GABBR2 include Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills, Rett syndrome- and Early Infantile Epileptic Encephalopathy 59.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N81/2

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

GABBR2 GPR51 GPRC3B

Molecular Weight

105 kDa

Antigen

Fusion protein amino acids 861-912 of rat GABABR2 (accession number NP_113990) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2939463

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

No cross-reactivity against GABABR1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)

UniProt Details

UniProt (Human): O75899
UniProt (Immunogen Species): O75899

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Anti-GABA-B-R2 Antibody FL650 Conjugate (N81/2)

SKU: 75-124-FL650

Product Details

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