Anti-GABA-B-R2 Antibody (N81/2)

Name: Anti-GABA-B-R2 Antibody
Brand: NeuroMab
SKU: 75-124
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

KO Validated

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse

Clone

N81/2

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

GABBR2 GPR51 GPRC3B

Molecular Weight

105 kDa

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Immunoblot against adult rat brain membranes (RBM) and membranes from GABABR2 wild-type (WT) and knockout (KO) mice probed with N81/2 (left) or N52A/42 (right) TC supe. Mouse brains courtesy of Joshua Walker and Stephen Moss (Tufts).

Immunoblot against crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N81/2 (left) or N52A/42 (right) TC supe.

Volume: 100 µL

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Product Details

Target

GABA(B)R2

Target Description

Gamma-aminobutyric acid type B receptor subunit 2 or GABA BR2 is encoded by the gene GABBR2. GABA BR2 is a subunit of the G-protein coupled receptor for the neurotransmitter GABA (gamma-aminobutyric acid). It will inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. GABA BR2 is highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus at the cell junction, synapse, the postsynaptic cell membrane and cytoplasmic vesicle membrane. It is weakly expressed in heart, testis and skeletal muscle. Diseases associated with GABBR2 include Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills, Rett syndrome- and Early Infantile Epileptic Encephalopathy 59.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N81/2

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABBR2 GPR51 GPRC3B

Molecular Weight

105 kDa

Antigen

Fusion protein amino acids 861-912 of rat GABABR2 (accession number NP_113990) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_10672845

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.51

Conjugate

Unconjugated

Specificity

No cross-reactivity against GABABR1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20)

UniProt Details

UniProt (Human): O75899
UniProt (Immunogen Species): O75899

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Anti-GABA-B-R2 Antibody (N81/2)

Available Conjugates

Anti-GABA-B-R2 Antibody
SKU: 75-124

Bulk Order Anti-GABA-B-R2 Antibody

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Anti-GABA-B-R2 Antibody (N81/2)

Available Conjugates

Anti-GABA-B-R2 Antibody SKU: 75-124

Bulk Order Anti-GABA-B-R2 Antibody

Product Details

Anti-GABA-B-R2 Antibody
SKU: 75-124