Bulk Order Anti-GABA-A-R, Alpha1 Antibody FL490 Conjugate
GABA(A)R, Alpha1 (Gamma-aminobutyric acid receptor subunit alpha-1) makes up two of the five subunits in the membrane bound GABA A receptor, the others being two β2 subunits and a single γ2 subunit. The receptor is a ligand gated chloride ion channel found postsynaptically and binds GABA, the major inhibitory neurotransmitter in the CNS. Mutations in GABA(A)R, Alpha1 have been linked to several types of epilepsy.
Purified by Protein A chromatography
Fusion protein amino acids 355-394 of mouse GABA-AR-Alpha1 (accession number P62812) produced recombinantly in E. Coli
Human, Mouse, Rat, Xenopus
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
No cross-reactivity against GABA-A-R-Alpha2 or -Alpha3
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.