Anti-GABA(A)R, Alpha1 Antibody (N95/35)

Name: Anti-GABA(A)R, Alpha1 Antibody
Brand: NeuroMab
SKU: 75-136
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated Trial Size

filler

Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRA1

Molecular Weight

55 kDa

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Immunoblot of adult mouse membranes from wild-type (WT) and GABA-A-R-Alpha1 knockout (KO) mice probed with N95/35 (green) and anti-actin polyclonal (red). Image courtesy of Dominique Arion, Kelly Rogers and David Lewis (University of Pittsburgh).

Adult rat brain immunohistochemistry (with antigen retrieval via pepsin pretreatment).

Immunoblot of adult mouse membranes from wild-type (WT) and GABA-A-R-Alpha1 knockout (KO) mice probed with N95/35 (green) and anti-actin polyclonal (red). Image courtesy of Dominique Arion, Kelly Rogers and David Lewis (University of Pittsburgh).

Volume: 100 µL

Variant

Price:

$345

Quantity:

Product Details

Target

GABA(A)R, Alpha1

Target Description

GABA(A)R, Alpha1 (Gamma-aminobutyric acid receptor subunit alpha-1) makes up two of the five subunits in the membrane bound GABA A receptor, the others being two ß2 subunits and a single ?2 subunit. The receptor is a ligand gated chloride ion channel found postsynaptically and binds GABA, the major inhibitory neurotransmitter in the CNS. Mutations in GABA(A)R, Alpha1 have been linked to several types of epilepsy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N95/35

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRA1

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 355-394 of mouse GABA-AR-Alpha1 (also known as gamma-aminobutyric acid receptor subunit alpha-1, accession number P62812); Rat: 100% identity (40/40 amino acids identical); Human: 100% identity (40/40 amino acids identical); Less than 50% identity with GABA-A-R-Alpha2 or -Alpha3

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2108811

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against GABA-A-R-Alpha2 or -Alpha3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1)

UniProt Details

UniProt (Human): P14867
UniProt (Immunogen Species): P14867

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Anti-GABA(A)R, Alpha1 Antibody (N95/35)

Anti-GABA(A)R, Alpha1 Antibody
SKU: 75-136

Product Details

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Anti-GABA(A)R, Alpha1 Antibody (N95/35)

Anti-GABA(A)R, Alpha1 Antibody SKU: 75-136

Product Details

Anti-GABA(A)R, Alpha1 Antibody
SKU: 75-136