Immunoblot of adult mouse membranes from wild-type (WT) and GABA-A-R-Alpha1 knockout (KO) mice probed with N95/35 (green) and anti-actin polyclonal (red). Image courtesy of Dominique Arion, Kelly Rogers and David Lewis (University of Pittsburgh).
Anti-GABA(A)R, Alpha1 Antibody
GABA(A)R, Alpha1 (Gamma-aminobutyric acid receptor subunit alpha-1) makes up two of the five subunits in the membrane bound GABA A receptor, the others being two ß2 subunits and a single ?2 subunit. The receptor is a ligand gated chloride ion channel found postsynaptically and binds GABA, the major inhibitory neurotransmitter in the CNS. Mutations in GABA(A)R, Alpha1 have been linked to several types of epilepsy.
ICC, IHC, WB
Fusion protein amino acids 355-394 of mouse GABA-AR-Alpha1 (also known as gamma-aminobutyric acid receptor subunit alpha-1, accession number P62812); Rat: 100% identity (40/40 amino acids identical); Human: 100% identity (40/40 amino acids identical); Less than 50% identity with GABA-A-R-Alpha2 or -Alpha3
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against GABA-A-R-Alpha2 or -Alpha3
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.