Anti-CSPG4/NG2 Recombinant Chicken Chimeric mAb (BSA and Azide free) (6203-34)

Name: Anti-CSPG4/NG2 Recombinant Chicken Chimeric mAb (BSA and Azide free)
Brand: Aves Labs
SKU: 78-523-CF
Price: 522.0 USD
Availability: InStock

Our chicken Anti-CSPG4/NG2 carrier-free recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone 6203-34. It detects human, mouse, and rat CSPG4/NG2 and is purified by affinity chromatography. It works in ELISA, ICC, IHC, WB.

Anti-CSPG4/NG2 Recombinant Chicken Chimeric mAb (BSA and Azide free)

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Conjugates and Formulations

490

550

594

650

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Data Sheet

Trial Size

SKU: 78-523-CF

Volume: 100 µL

Variant

Price:

$522.00

Quantity:

Ships: 1-2 business days

Product Details

Target

CSPG4/NG2

Scientific Background

Neuron-glial antigen 2 (NG2) is a chondroitin sulfate proteoglycan that is encoded by the CSPG4 gene in humans. It is an excellent oligodendrocyte marker. NG2 is a hallmark protein of oligodendrocyte progenitor cells (OPCs) and has been linked with familial schizophrenia (de Vrij, F.M., et al, 2018). NG2 also plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells (Luo, W., et al, 2006). NG2 localizes at the apical plasma membrane and relocalizes to the lamellipodia of astrocytoma upon PRKCA phosphorylation.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

6203-34

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Gene Name

CSPG4/NG2

Molecular Weight

250 kDa

Excitation / Emission

Unconjugated

Immunogen

Fusion protein amino acids S1583-S2224 of human CSPG4/NG2 (accession number Q6UVK1) produced in CHO cells

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone 6203-34 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone 6203-34 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Buffer

PBS

Dilution Ranges

WB: 1:100-1:1000
WB Brain: 1:100-1:1000
IHC: 1:100-1:250
ICC: 1:100-1:250

Conjugate

Unconjugated, Carrier Free

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Chondriotin Sulfate Proteoglycan 4, CSPG4, NG2, MSK16, MCSPG, Chondroitin Sulfate Proteoglycan NG2

UniProt ID

Q6UVK1

Shipping

Shipped on ice packs

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Anti-CSPG4/NG2 Recombinant Chicken Chimeric mAb (BSA and Azide free) (6203-34)

SKU: 78-523-CF

Product Details

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