Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Name: Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
Brand: NeuroMab
SKU: 75-143
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

ATP7B PWD WC1 WND

Molecular Weight

160 kDa in rat brain membrane preparations

Go to Full Product Details

Immunoblot versus rat brain membranes (RBM), rat liver membranes (RLM) and lysates of COS-1 cells transfected with human Copper- transporting ATPase 2 (COS+) or empty vector (COS-) and probed with L62/29 tissue culture supernatant.

Product Details

Target

Copper ATPase 2 (Wilson's disease protein)

Target Description

Copper-transporting ATPase 2 or Copper-transporting ATPase Beta is encoded by the gene ATP7B and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 2 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the golgi network and is also to remove excess copper across plasma membranes out of the cell Copper-transporting ATPase 2 is expressed in liver and in lower leves in brain, heart, kidney, placenta and lung. In liver, it is involved in removing copper from hepatocytes into the bile for removal. Diseases associated with this gene include Wilson Disease and Menkes Disease.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L62/29

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

ATP7B PWD WC1 WND

Molecular Weight

160 kDa in rat brain membrane preparations

Antigen

Synthetic peptide amino acids 3-21 (cytoplasmic N- terminus) of human Copper-transporting ATPase 2 (Copper pump 2) (Wilsons disease-associated protein) (accession number P35670); Rat: 78% identity (15/19 amino acids); Mouse=84% identity (16/19 amino acids)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2290260

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Copper-transporting ATPase 2 (EC 3.6.3.54) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]

UniProt Details

UniProt (Human): P35670
UniProt (Immunogen Species): P35670

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Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
SKU: 75-143

Product Details

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Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody SKU: 75-143

Product Details

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
SKU: 75-143