Immunoblot versus rat brain membranes (RBM), rat liver membranes (RLM) and lysates of COS-1 cells transfected with human Copper- transporting ATPase 2 (COS+) or empty vector (COS-) and probed with L62/29 tissue culture supernatant.
Copper-transporting ATPase 2 or Copper-transporting ATPase Beta is encoded by the gene ATP7B and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 2 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the golgi network and is also to remove excess copper across plasma membranes out of the cell Copper-transporting ATPase 2 is expressed in liver and in lower leves in brain, heart, kidney, placenta and lung. In liver, it is involved in removing copper from hepatocytes into the bile for removal. Diseases associated with this gene include Wilson Disease and Menkes Disease.