Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Name: Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
Brand: NeuroMab
SKU: 75-143
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

L62/29

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

ATP7B PWD WC1 WND

Molecular Weight

160 kDa in rat brain membrane preparations

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Immunoblot versus rat brain membranes (RBM), rat liver membranes (RLM) and lysates of COS-1 cells transfected with human Copper- transporting ATPase 2 (COS+) or empty vector (COS-) and probed with L62/29 tissue culture supernatant.

Volume: 100 µL

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Product Details

Target

Copper ATPase 2 (Wilson's disease protein)

Target Description

Copper-transporting ATPase 2 or Copper-transporting ATPase Beta is encoded by the gene ATP7B and belongs to the cation transport ATPase (P-type) family. Copper-transporting ATPase 2 is a transmembrane enzyme that functions to provide copper to copper requiring proteins in the golgi network and is also to remove excess copper across plasma membranes out of the cell Copper-transporting ATPase 2 is expressed in liver and in lower leves in brain, heart, kidney, placenta and lung. In liver, it is involved in removing copper from hepatocytes into the bile for removal. Diseases associated with this gene include Wilson Disease and Menkes Disease.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L62/29

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

ATP7B PWD WC1 WND

Molecular Weight

160 kDa in rat brain membrane preparations

Antigen

Synthetic peptide amino acids 3-21 (cytoplasmic N- terminus) of human Copper-transporting ATPase 2 (accession number P35670)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2290260

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.69

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Copper-transporting ATPase 2 (EC 3.6.3.54) (Copper pump 2) (Wilson disease-associated protein) [Cleaved into: WND/140 kDa]

UniProt Details

UniProt (Human): P35670
UniProt (Immunogen Species): P35670

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Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Available Conjugates

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
SKU: 75-143

Bulk Order Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody

Product Details

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Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody (L62/29)

Available Conjugates

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody SKU: 75-143

Bulk Order Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody

Product Details

Anti-Copper ATPase 2 (Wilson's Disease Protein) Antibody
SKU: 75-143