Anti-Chapsyn-110 MAGUK Antibody FL550 Conjugate (N18/28)

Name: Anti-Chapsyn-110 MAGUK Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-284-FL550
Price: 460.0 USD
Availability: InStock

Our Anti-Chapsyn-110 MAGUK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N18/28. It is KO validated, detects human, mouse, and rat Chapsyn-110 MAGUK, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Chicken, Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

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Data Sheet

KO Validated

SKU: 75-284-FL550

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Chapsyn-110 MAGUK

Target Description

PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N18/28

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli

Species Reactivity

Chicken, Human, Mouse, Rat

Antibody Registry ID

AB_2940013

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Does not cross-react with SAP97, SAP102 or PSD-95

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

UniProt Details

UniProt (Human): Q15700
UniProt (Immunogen Species): Q63622

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Anti-Chapsyn-110 MAGUK Antibody FL550 Conjugate (N18/28)

SKU: 75-284-FL550

Product Details

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