Name: Anti-Chapsyn-110 MAGUK Antibody
Brand: NeuroMab
SKU: 75-284
Price: 295.0 USD
Availability: InStock

Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

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Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.

Immunofluorescence staining of 14 DIV cultured rat hippocampal neurons.

Adult rat brain hippocampus immunohistochemistry.

Adult rat Cerebellum immunohistochemistry.

Immunoblot against crude membrane preparations from adult rat brain (RBM) or hippocampi from adult wild-type (WT) or PSD- 93/Chapsyn-110 knockout (KO) mice probed with N18/28 (left) or K28/86 (right) TC supe. Mouse samples courtesy of Richard Huganir (Johns Hopkins University).

Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.

Product Details

Target

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

Target Description

PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N18/28

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Dlg2 Dlgh2

Molecular Weight

110 kDa

Antigen

Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2, Dlg2 and Dlgh2, accession number Q63622); Mouse: 99% identity (846/852 amino acids identical ; Human: 94% identity (826/870 amino acids identical); Greater than 60% identity with other MAGUK family members (SAP97/Dlg1, SAP102/Dlg3 and PSD-95/Dlg4)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_11001825

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with SAP97, SAP102 or PSD-95

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)

UniProt Details

UniProt (Human): Q15700
UniProt (Immunogen Species): Q63622

Citations (3)

Fasoli A1, Dang J1, Johnson JS1, Gouw AH1, Fogli Iseppe A1, Ishida AT1,2. (2017), 'Somatic and neuritic spines on tyrosine hydroxylase-immunopositive cells of rat retina..' J Comp Neurol. 10.1002/cne.24166.
Liu Y1, Lee JW1, Ackerman SL2. (2015), 'Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration..' J Neurosci. 10.1523/JNEUROSCI.2757-14.2015.
Fujikawa T1, Petralia RS2, Fitzgerald TS3, Wang YX4, Millis B5, Morgado-Díaz JA6, Kitamura K7, Kachar B5. (2014), 'Localization of kainate receptors in inner and outer hair cell synapses..' Hear Res. 10.1016/j.heares.2014.05.001.

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Anti-Chapsyn-110 MAGUK Antibody (N18/28)

Anti-Chapsyn-110 MAGUK Antibody
SKU: 75-284

Product Details

Citations (3)

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Anti-Chapsyn-110 MAGUK Antibody (N18/28)

Anti-Chapsyn-110 MAGUK Antibody SKU: 75-284

Product Details

Citations (3)

Anti-Chapsyn-110 MAGUK Antibody
SKU: 75-284