Our Anti-Chapsyn-110 MAGUK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N18/28. It is KO validated, detects human, mouse, and rat Chapsyn-110 MAGUK, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.
PSD-93/Chapsyn-110 (also known as Channel-associated protein of synapse-110, Postsynaptic density protein PSD-93, Disks large homolog 2 and Dlg2) is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains a guanylate kinase-like domain, 3 PDZ domains and 1 SH3 domain. Chapsyn110 binds to NMDA receptor subunits and Shaker K+ channel subunits to aid in forming a multiprotein scaffold which clusters receptors, ion channels, cytoskeletal protiens and other cell signaling proteins. In this manner, it plays a key role in postsynaptic targeting. It is found in brain in neuronal cells and located at the cell synapse, postsynaptic cell membrane and postsynaptic density. Chapsyn110 has been implicated in chronic pain, bilateral retinoblastoma and schizophrenia.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N18/28
IgG2a
ICC, IHC, WB
Mouse
Dlg2 Dlgh2
110 kDa
Fusion protein amino acids 1-852 (full-length) of rat Chapsyn-110 (accession number Q63622) produced recombinantly in E. Coli
Chicken, Human, Mouse, Rat
AB_11001825
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
WB: 1:1000
IHC: 1:250
ICC: 1:250
Unconjugated
Does not cross-react with SAP97, SAP102 or PSD-95
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93)
Djemil, S., et al. 2020. Central Cholinergic Synapse Formation in Optimized Primary Septal-Hippocampal Co-Cultures.. Cellular and Molecular Neurobiology, .
Fasoli, A., et al. 2017. Somatic and neuritic spines on tyrosine hydroxylase-immunopositive cells of rat retina.. Journa of Comparative Neurology, 1707-1730.
Liu, Y., et al. 2015. Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration.. Journal of Neuroscience, 4587-4598.
Fasoli, A., et al. 2017. Somatic and neuritic spines on tyrosine hydroxylase-immunopositive cells of rat retina.. Journa of Comparative Neurology, 1707-1730.
Liu, Y., et al. 2015. Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration.. Journal of Neuroscience, 4587-4598.
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![Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-284-n18-28-wb2_{width}x.jpg?v=1626903977)
![Immunoblot against crude membranes from whole adult mouse brain (MBM) or rat brain (RBM) and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with N18/28 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-284-n18-28-wb2_1024x.jpg?v=1626903977)
KO Validated