Anti-Celf4/Brunol4 Antibody FL490 Conjugate (N446/80)

Name: Anti-Celf4/Brunol4 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-438-FL490
Price: 486.0 USD
Availability: InStock

Our mouse Celf4/Brunol4 FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N446/80. It detects human, mouse, and rat Celf4/Brunol4 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-Celf4/Brunol4 Antibody FL490 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-438-FL490

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Celf4/Brunol4

Scientific Background

CUGBP Elav-like family member 4 (CELF4), or Brunol4 is encoded by the gene CELF4. CELF4 is a RNA-binding protein which is involved in the regulation of pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. CELF4 is expressed ubiquitously in tissues, and strongly expressed in brain. Diseases associated with CELF4 include Speech and Communication Disorders and Specific Language Impairment.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N446/80

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

CELF4 BRUNOL4

Molecular Weight

50 kDa

Immunogen

Fusion protein amino acids 2-87 (N-terminus) of human Celf4 (accession number Q9BZC1) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940460

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with Celf6

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

BRUNOL4; CUGBP Elav-like family member 4; CELF-4; CUG-BP- and ETR-3-like factor 4; Bruno-like protein 4; LYST-interacting protein LIP9; RNA-binding protein BRUNOL4; RNA-binding protein BRUNOL-4; bruno-like 4; RNA binding protein

UniProt ID

Q9BZC1
UniProt Summary: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

NCBI Gene ID

56853

Shipping

Shipped on ice packs

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Anti-Celf4/Brunol4 Antibody FL490 Conjugate (N446/80)

SKU: 75-438-FL490

Product Details

Bulk Order Anti-Celf4/Brunol4 Antibody FL490 Conjugate

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