Voltage-dependent L-type calcium channel subunit beta-2 or Cav ß2 is encoded by the gene CACNB2. Cavß2 is a cytoplasmic subunit of L type voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß2 is expressed heart and brain, and lung. Mutations in this gene are associated with Brugada syndrome.
IHC, IP, WB
Synthetic peptide amino acids 189-205 of rat Cav2 (RSPKPSANSVTSPHSKE; accession number A0A0G2JSZ0); Human: 100% identity; Mouse: 100% identity; Common to all Cav2 splice variants
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Cavβ1, Cavβ3, Cavβ4
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.