Anti-Cav3.2 Ca2+ Channel Antibody (N55/10)

Name: Anti-Cav3.2 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-095
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

filler

Clonality

Monoclonal

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

CACNA1H

Molecular Weight

260 kDa

Go to Full Product Details

Immunohistochemistry of coronal brain sections from WT and Cav3.2 KO mice. Reproduced with permission from Mala Shah (University College London, England, UK) and Nature Neuroscience (2011, Huang et al., PMID 21358644).

Stable cell immunoblot: extracts of HEK cells stably-expressing Flag-tagged Cav3.2, Cav3.1 or untagged Kv2.1 plasmid and probed with N55/10 TC supe (left) or Rabbit anti-Flag (right).

Product Details

Target

Cav3.2 Ca2+ channel

Target Description

Voltage-dependent T-type calcium channel subunit alpha-1H or Cav3.2 Ca2+ channel is encoded by the gene CACNA1H. Cav3.2 is a pore forming alpha subunit of T voltage-sensitive calcium channels and gives rise to T-type calcium currents. (transient opening calcium channels). These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav3.2 is expressed in kidney, liver, and heart and brain.as a membrane bound protein. Diseases associated with this gene include Hyperaldosteronism and Epilepsy.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N55/10

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

CACNA1H

Molecular Weight

260 kDa

Antigen

Fusion protein amino acids 1019-1293 (cytoplasmic loop between repeat II and repeat III) of human Cav3.2 (also known as Voltage-dependent T-type calcium channel subunit alpha-1H, Low-voltage-activated calcium channel alpha1 3.2 subunit, CACNA1H and Kiaa1120, accession number O95180), epitope mapped to amino acids 1179-1192 (AEDGRAAPGPRATP) Rat: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical); Mouse: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical)

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2315827

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

Does not cross-react with Cav3.1

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-dependent T-type calcium channel subunit alpha-1H (Low-voltage-activated calcium channel alpha1 3.2 subunit) (Voltage-gated calcium channel subunit alpha Cav3.2)

UniProt Details

UniProt (Human): O95180
UniProt (Immunogen Species): O95180

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Anti-Cav3.2 Ca2+ Channel Antibody (N55/10)

Anti-Cav3.2 Ca2+ Channel Antibody
SKU: 75-095

Product Details

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Anti-Cav3.2 Ca2+ Channel Antibody (N55/10)

Anti-Cav3.2 Ca2+ Channel Antibody SKU: 75-095

Product Details

Anti-Cav3.2 Ca2+ Channel Antibody
SKU: 75-095