Stable cell immunoblot: extracts of HEK cells stably-expressing Flag-tagged Cav3.2, Cav3.1 or untagged Kv2.1 plasmid and probed with N55/10 TC supe (left) or Rabbit anti-Flag (right).
Anti-Cav3.2 Ca2+ Channel Antibody
Cav3.2 Ca2+ channel
Voltage-dependent T-type calcium channel subunit alpha-1H or Cav3.2 Ca2+ channel is encoded by the gene CACNA1H. Cav3.2 is a pore forming alpha subunit of T voltage-sensitive calcium channels and gives rise to T-type calcium currents. (transient opening calcium channels). These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav3.2 is expressed in kidney, liver, and heart and brain.as a membrane bound protein. Diseases associated with this gene include Hyperaldosteronism and Epilepsy.
ICC, IHC, IP, WB
Fusion protein amino acids 1019-1293 (cytoplasmic loop between repeat II and repeat III) of human Cav3.2 (also known as Voltage-dependent T-type calcium channel subunit alpha-1H, Low-voltage-activated calcium channel alpha1 3.2 subunit, CACNA1H and Kiaa1120, accession number O95180), epitope mapped to amino acids 1179-1192 (AEDGRAAPGPRATP) Rat: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical); Mouse: 77% identity (224/279 amino acids identical), 54% identity for epitope (12/22 amino acids identical), 89% identity for highlighted epitope sequence (8/9 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Cav3.1
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.