Brain-derived neurotrophic factor is encoded by the gene BDNF and is a member of the neurotrophin family of growth factors. BDNF is a secreted signaling molecule with may important functions including axonal growth, modulation of dendritic growth, the promotion of survival/differentiation of neuronal populations in peripheral and central nervous systems, regulation of synaptic transmission/plasticity and long-term potentiation. BDNF is expressed highly in brain (in the hippocampus, amygdala, cerebral cortex and cerebellum) and expressed in lung, heart and skeletal muscle. Diseases associated with this gene include Congenital Central Hypoventilation Syndrome, Wilms Tumor, Aniridia and Mental Retardation Syndrome.
Purified by Protein A chromatography
Fusion protein amino acids 1-249 (full length) of mouse BDNF (accession number P21237) produced recombinantly in E. Coli
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.