Anti-BBS3/Arl6 Antibody FL650 Conjugate (N302/10)

Name: Anti-BBS3/Arl6 Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-270-FL650
Price: 486.0 USD
Availability: InStock

Our mouse BBS3/Arl6 FL650 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N302/10. It detects human, mouse, and rat BBS3/Arl6 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-BBS3/Arl6 Antibody FL650 Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 75-270-FL650

Volume: 200 µL

Variant

Price:

$486.00

Quantity:

Ships: 1-5 business days

Product Details

Target

BBS3/Arl6

Scientific Background

ADP-ribosylation factor-like protein 6, Bardet-Biedl syndrome 3 protein or BBS3/Arl6 is encoded by the gene ARL6 and is a member of the ARF family withing the small GTPase superfamily. BBS3 acts as a regulator of cellular traffic and has roles in protein transport and membrane trafficking. BBS3 is widely expressed in tissues including brain, eye, heart and kidney. Mutations in this gene are associated with Bardet-Biedl syndrome (BBS).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N302/10

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

ARL6 BBS3

Molecular Weight

20 kDa

Immunogen

Fusion protein amino acids 1-186 (full-length) of human ADP-ribosylation factor-like protein 6 (accession number Q9H0F7) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939971

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

BBS3; ADP-ribosylation factor-like protein 6; Bardet-Biedl syndrome 3 protein

UniProt ID

Q9H0F7
UniProt Summary: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.

NCBI Gene ID

84100

Shipping

Shipped on ice packs

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Anti-BBS3/Arl6 Antibody FL650 Conjugate (N302/10)

SKU: 75-270-FL650

Product Details

Bulk Order Anti-BBS3/Arl6 Antibody FL650 Conjugate

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