Anti-Arl13b Recombinant Guinea Pig Chimeric mAb (BSA and Azide Free) (N295B/66)

Name: Anti-Arl13b Recombinant Guinea Pig Chimeric mAb (BSA and Azide Free)
Brand: Antibodies Incorporated
SKU: 74-287-CF
Price: 522.0 USD
Availability: InStock

Our guinea pig Anti-Arl13b carrier-free recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N295B/66. It detects human, mouse, non-human primate, rat, and zebrafish Arl13b and is purified by affinity chromatography. KO validated. Works in WB, IHC, ICC, ELISA.

Anti-Arl13b Recombinant Guinea Pig Chimeric mAb (BSA and Azide Free)

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Species Reactivity

Human, Mouse, Non-Human Primate, Rat, Zebrafish

Applications

ELISA, ICC, IHC, WB

Host Species

Guinea Pig

Conjugates and Formulations

Unconjugated

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 74-287-CF

Volume: 100 µL

Variant

Price:

$522.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Arl13b

Scientific Background

ADP-ribosylation factor-like protein 13B (ARL13B), also known as ADP-ribosylation factor-like protein 2-like 1. Arl13B is a small GTPase with both N-terminal and C-terminal guanine nucleotide-binding motifs. Arl13B is localized to the membrane of cilia and expressed in Neuroepithelial cells and developing radial glia of the developing cerebral cortex. Mutations in this gene are the cause of Joubert syndrome 8.

Format

Purified by affinity chromatography

Concentration

1 mg/mL

Clonality

Recombinant

Clone

N295B/66

Isotype

IgG

Applications

ELISA, ICC, IHC, WB

Host Species

Guinea Pig

Gene Name

Arl13b Arl2l1

Molecular Weight

50 kDa

Excitation / Emission

Unconjugated

Immunogen

Fusion protein amino acids 208-427 (C-terminus) of mouse Arl13b (accession number Q640N2) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Non-Human Primate, Rat, Zebrafish

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N295B/66 with guinea pig IgG heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N295B/66 but can be detected using standard anti-guinea pig secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and buffer exchanged into 1X PBS.

Buffer

PBS

Dilution Ranges

WB: 1:1000

Conjugate

Unconjugated

Specificity

Does not cross-react with Arl13a (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

A530097K21Rik; ADP-ribosylation factor-like protein 13B; Arl2l1; ADP-ribosylation factor-like protein 2-like 1; C530009C10Rik; ARL2-like protein 1; hnn; Protein hennin; ADP-ribosylation factor-like 2-like 1

UniProt ID

Q640N2
UniProt Summary: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex. Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis. May regulate ARF6- and RAB22A-dependent endocytic recycling traffic.

NCBI Gene ID

68146

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Anti-Arl13b Recombinant Guinea Pig Chimeric mAb (BSA and Azide Free) (N295B/66)

SKU: 74-287-CF

Product Details

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