Anti-Stargazin Antibody

Name: Anti-Stargazin Antibody
Brand: PhosphoSolutions
SKU: 1505-STAR
Price: 456.0 USD
Availability: InStock

Our Anti-Stargazin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat Stargazin and is antigen affinity purified from pooled serum. It is great for use in WB.

Western blot of rat synaptic plasma membrane (SPM) lysate showing specific immunolabeling of the ~36 kDa stargazin protein.

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Species Reactivity

Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

Trial Size

Pooled Serum

SKU: 1505-STAR

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Stargazin

Scientific Background

Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr-321- by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

CACNG2

Molecular Weight

36 kDa

Immunogen

Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat Stargazin, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Species

Rat

Species Reactivity

Rat

Expected Reactivity

Mouse

Antibody Registry ID

AB_2492240

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from rabbit serum by affinity purification using a column to which the C-terminal peptide imunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~36kDa stargazin protein. Immunolabeling of the stargazin band is blocked by preadsorption with the peptide used as antigen.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

AW060990; B230105C07Rik; B930041E13Rik; Cacng2; Calcium channel voltage dependent gamma subunit 2; CaV gamma 2; CCG2_HUMAN; Ipr328; MGC123981; MGC138502; MGC138504; Neuronal voltage gated calcium channel gamma 2 subunit; Neuronal voltage-gated calcium channel gamma-2 subunit; Stargazer; stg; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; Voltage dependent calcium channel gamma 2 subunit; Voltage-dependent calcium channel gamma-2 subunit; Wag; Waggler

UniProt ID

O88602
UniProt Summary: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000269|PubMed:20805473}.

NCBI Gene ID

12300

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Anti-Stargazin Antibody

SKU: 1505-STAR

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