Anti-VMAT1 Antibody Biotin Conjugate (N440/61)

Name: Anti-VMAT1 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-431-BTN
Price: 543.0 USD
Availability: InStock

Our mouse VMAT1 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N440/61. It detects mouse and rat VMAT1 and is purified by Protein A chromatography. Works in ELISA, IHC, ICC.

Anti-VMAT1 Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-431-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

VMAT1

Scientific Background

Vesicular monamine transporters (VMATs) sequester neurotransmitters such as dopamine, serotonin and adrenaline into synaptic vesicles (Erickson et al., 1996). Two VMATs have been identified, VMAT1 and VMAT2. VMAT1 shows a higher affinity for serotonin (Brunk et al., 2006). Antibodies specific for VMATs have been used to monitor expression of the transporter during development and in aging and can be effectively used as a marker for monoamine terminals (Haycock et al., 2003; Witkovsky et al., 2005).

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N440/61

Isotype

IgG2a

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Slc18a1 Vmat1

Molecular Weight

100 kDa

Immunogen

Fusion Protein Amino acids 43-135 (first lumenal domain) of mouse Slc18a1 (accession number Q8R090) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with VMAT2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

4832416I10Rik; Chromaffin granule amine transporter; Vmat1; Solute carrier family 18 member 1; Vesicular amine transporter 1; VAT1

UniProt ID

Q8R090
UniProt Summary: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin. Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli.

NCBI Gene ID

110877

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Shipped on ice packs

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Anti-VMAT1 Antibody Biotin Conjugate (N440/61)

SKU: 75-431-BTN

Product Details

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