Anti-VMAT1 Antibody (N440/61)

Name: Anti-VMAT1 Antibody
Brand: NeuroMab
SKU: 75-431
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N440/61

Applications

ICC, IHC

Host Species

Mouse

Format

Purified

Gene Name

Slc18a1 Vmat1

Molecular Weight

100 kDa

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Adult rat brain immunohistochemistry.

Volume: 100 µL

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$308

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Product Details

Target

Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)

Target Description

Vesicular monamine transporters (VMATs) sequester neurotransmitters such as dopamine, serotonin and adrenaline into synaptic vesicles (Erickson et al., 1996). Two VMATs have been identified, VMAT1 and VMAT2. VMAT1 shows a higher affinity for serotonin (Brunk et al., 2006). Antibodies specific for VMATs have been used to monitor expression of the transporter during development and in aging and can be effectively used as a marker for monoamine terminals (Haycock et al., 2003; Witkovsky et al., 2005).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N440/61

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Slc18a1 Vmat1

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 43-135 (first lumenal domain) of mouse Slc18a1 (also known as Solute carrier family 18 member 1, Vesicular amine transporter 1, Chromaffin granule amine transporter, VAT1, VMAT1 and Cgat, accession number Q8R090); Rat: 92% identity (86/93 amino acids identical); Human: 65% identity (62/96 amino acids identical); 30% identity with Slc18a2/VMAT2

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2632412

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with VMAT2

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)

UniProt Details

UniProt (Human): P54219
UniProt (Immunogen Species): Q8R090

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Anti-VMAT1 Antibody (N440/61)

Anti-VMAT1 Antibody
SKU: 75-431

Bulk Order Anti-VMAT1 Antibody

Product Details

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Anti-VMAT1 Antibody (N440/61)

Anti-VMAT1 Antibody SKU: 75-431

Bulk Order Anti-VMAT1 Antibody

Product Details

Anti-VMAT1 Antibody
SKU: 75-431