Anti-VAChT Antibody Biotin Conjugate (N425/45)

Name: Anti-VAChT Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-429-BTN
Price: 543.0 USD
Availability: InStock

Our mouse VAChT biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N425/45. It detects mouse and rat VAChT and is purified by Protein A chromatography. Works in ELISA, IHC, ICC.

Anti-VAChT Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-429-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

VAChT

Scientific Background

Vesicular acetylcholine transporter (VaCht), or Solute Carrier Family 18 Member A3 is encoded by the gene Slc18a3 and is a member of the vesicular amine transporter family. VaCht transports acetylcholine into secretory vesicles for release into the extracellular space. VaCht is expressed in major cholinergic cell groups in the peripheral and central cholinergic nervous systems. Diseases associated with SLC18A3 include Myasthenic Syndrome and Presynaptic and Presynaptic Congenital Myasthenic Syndromes.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N425/45

Isotype

IgG1

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Slc18a3 Vacht Vat

Molecular Weight

60 kDa

Immunogen

Fusion Protein Amino acids 55-125 (first vesicle lumen domain) of rat VAChT (accession number Q62666) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with VMAT1 or VMAT2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

VACht; Vesicular acetylcholine transporter; rVAT; Solute carrier family 18 member 3

UniProt ID

Q62666
UniProt Summary: Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin.

NCBI Gene ID

60422

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Anti-VAChT Antibody Biotin Conjugate (N425/45)

SKU: 75-429-BTN

Product Details

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