Anti-TrpV1 Antibody (N221/17)

Name: Anti-TrpV1 Antibody
Brand: NeuroMab
SKU: 75-254
Price: 337.0 USD
Availability: InStock

Our mouse TrpV1 monoclonal antibody from NeuroMab is produced in-house from clone N221/17. It detects mouse and rat TrpV1 and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Immunofluorescence staining of adult dorsal root ganglion sections from TrpV1 WT and -/- mice with N221/17 TC supe (red), Kv1.2 rabbit polyclonal (green) and Hoechst nuclear stain (blue). Images courtesy of Matthew Rasband (Baylor College of Medicine).

Adult rat spinal cord dorsal horn immunohistochemistry.

Immunofluorescence staining of adult dorsal root ganglion sections from TrpV1 WT and -/- mice with N221/17 TC supe (red), Kv1.2 rabbit polyclonal (green) and Hoechst nuclear stain (blue). Images courtesy of Matthew Rasband (Baylor College of Medicine).

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-254

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

TrpV1

Scientific Background

Transient receptor potential cation channel subfamily V (vanilloid) member 1, or TrpV1 is a member of transient receptor potential cation channel family(TRP channel).TrpV1 is a non-selective, ligand activated calcium permeant cation channel that is widely expressed in tissues but elevated in dorsal root ganglia, highly but not solely expressed in postsynaptic dendritic spines. TrpV1 is involved in heat and chemical detection and in pain perception.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N221/17

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Trpv1 Vr1 Vr1l

Molecular Weight

100 kDa

Immunogen

Fusion protein amino acids 1-160 (cytoplasmic N-terminus) of rat TrpV1 (accession number O35433) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_11000725

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:1000
IHC: 1:100
ICC: 1:100

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Vanilloid receptor type 1-like)

UniProt ID

O35433

Shipping

Shipped on ice packs

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Anti-TrpV1 Antibody (N221/17)

SKU: 75-254

Product Details

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