Anti-TRAAK Potassium Channel Antibody Biotin Conjugate (N445/27)

Name: Anti-TRAAK Potassium Channel Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-433-BTN
Price: 543.0 USD
Availability: InStock

Our mouse TRAAK potassium channel biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N445/27. It detects mouse and rat TRAAK potassium channel and is purified by Protein A chromatography. Works in ELISA, IHC, ICC.

Anti-TRAAK Potassium Channel Antibody Biotin Conjugate

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-433-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

TRAAK potassium channel

Scientific Background

Potassium two pore domain channel subfamily K member 4 is encoded by the gene KCNK4. KCNK4 is a member of the two pore domain potassium channel (TC 1.A.1.8) family. KCNK4 homodimerizes and functions as an outwardly rectifying channel. KCNK4 is regulated by polyunsaturated fatty acids, temperature, and mechanical deformation of the lipid membrane. KCNK4 is expressed in the brain, spinal cord, and eye. Diseases associated with KCNK4 include Facial Dysmorphism, Hypertrichosis, Epilepsy, Intellectual/Developmental Delay, and Gingival Overgrowth Syndrome.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N445/27

Isotype

IgG2a

Applications

ELISA, ICC, IHC

Host Species

Mouse

Gene Name

Kcnk4 Traak

Molecular Weight

43 kDa

Immunogen

Fusion Protein Amino acids 256-398 (cytoplasmic C-terminus) of mouse TRAAK (accession number O88454) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

Does not cross-react with TREK1/KCNK2

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Catsperz; Potassium channel subfamily K member 4; TRAAK; TWIK-related arachidonic acid-stimulated potassium channel protein; TRAAKt; Tex40; catSper-zeta; catSperzeta; testis-expressed protein 40

UniProt ID

O88454
UniProt Summary: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, temperature and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses. Permeable to other monovalent cations such as Rb(+) and Cs(+).

NCBI Gene ID

16528

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Anti-TRAAK Potassium Channel Antibody Biotin Conjugate (N445/27)

SKU: 75-433-BTN

Product Details

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